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Pediatric Neuroscience Trials


If you would like to learn more about participating in a research study or clinical trial, email us at

Pediatric Neurosurgery

Methotrexate Infusion into the Fourth Ventricle in Children with Malignant Fourth Ventricular Brain Tumors: A Pilot Study
Principal Investigator: David Sandberg, M.D.

This clinical trial will be conducted at Children's Memorial Hermann Hospital and the University of Texas MD Anderson Cancer Center.  This novel treatment approach, based upon many years of translational research in animals by the principal investigators, will be available to patients ages 0 to 22 years old with recurrent medulloblastoma, ependymoma, and atypical teratoid/rhabdoid tumor.  Patients will undergo surgical implantation of a catheter into the fourth ventricle of the brain which will be attached to a reservoir. Methotrexate, a chemotherapeutic agent, will be administered into the reservoir in three cycles to treat tumor recurrences in the both the brain and spine.

Non-Operative Management of Suspected Eosinophilic Granuloma of Skull
Principal Investigator: David Sandberg, M.D.

This multi-center study will be performed at centers of excellence in pediatric neurosurgery in North America.  Children's Memorial Hermann Hospital is a participating site. This is an observational study in which patients (ages 0 to21) with suspected eosinophilic granulomas of the skull, a condition which is typically treated with surgical resection, will be offered observation alone. We hypothesize that many such lesions will resolve without treatment and that surgery is not necessary in the majority of patients.

Pediatric Clinical Study of the Durepair Dura Regeneration Matrix
Principal Investigator: Stephen Fletcher, D.O.

Fronto-basal-ganglia circuits for selective stopping and braking
Principal Investigator: Nitin Tandon, M.D.

This project uses intra-cranial brain recordings and fMRI to understand the dynamics of the brain substrates involved in cognitive control.

Pediatric Neurology

Academic Outcomes After Traumatic Brain Injury in Children and Adolescents
Principal Investigator: Linda Ewing-Cobbs, Ph.D.

This study aims to describe the interrelationships between traumatic brain injury (TBI) severity, demographics, age at injury and academic outcomes in reading, math and written language.

Accidental and Non-accidental Pediatric Brain Injury (Child Injury Project)
Principal Investigator: Linda Ewing-Cobbs, Ph.D.

Researchers are evaluating the skill development of brain-injured children based on the age at which the traumatic brain injury (TBI) occurred. They are also assessing how biological and social factors affect outcomes in accidental and non-accidental TBI.

Medical Etiologies of Neurodevelopmental Disorders
Principal Investigator: Richard Frye, M.D.

Investigators are determining if it is possible to identify early signs of disorders in the development of the nervous system to improve diagnosis and better determine patients’ prospects of survival and recovery.

Neurobehavioral Outcome of Head Injury in Children
Principal Investigator: Linda Ewing-Cobbs, Ph.D.

The research team is examining the relationship of certain executive function deficits involving working memory, inhibition and cognitive skills to the acute severity of closed-head injury (CHI), imaging of focal brain lesions and age differences. They are also investigating how these skills are related to communication, academic achievement, adaptive behavior and psychiatric outcome of CHI in children.

Outcomes Analysis of Hypertonic Saline Versus Mannitol in Pediatric Head Trauma: A Case Control Study
Principal Investigator: Nathan Strobel, M.D.

Implementation of the use of hypertonic saline, a salt solution, began in May 2002. This retrospective chart review, conducted from February 1998 through February 2008, will provide 6 years of historical data for comparison of the use of hypertonic saline versus mannitol, a diuretic.

Safety in Autologous Stem Cell Treatment for Traumatic Brain Injury in Children
Principal Investigator: Charles Cox, M.D.

In this pilot study, researchers are determining if bone marrow aspiration, a procedure to collect bone marrow for injection into the body, can be safely performed in children who have suffered a head injury.