Dedicated CDH Research
Children who qualify have opportunity to participate in groundbreaking research studies conducted by the physicians at McGovern Medical School. The team not only strives to provide unparalleled care today but is fervently seeking the innovative therapies of tomorrow.
Based on international data collected, 30 percent of children born with a diaphragmatic hernia do not survive, and in many cases these parents make the decision to donate tissue for research as a way to help future children with CDH. The risk of death is related to the size of the diaphragmatic defect, associated anomalies, and the lung development. Working to decrease that number, physicians affiliated with Children’s Memorial Hermann Hospital are actively participating in basic, translational, and clinical research to improving the lives of patients with CDH.
The affiliated team of CDH specialists – including fetal surgery, pediatric surgery and neonatology – are dedicated to research and innovation for the prenatal and postnatal treatment CDH.
- The Fetal Center, and the affiliated physicians at McGovern Medical School at UTHealth, offers fetoscopic endoluminal tracheal occlusion (FETO) for the prenatal treatment of severe CDH, as part of a national research study for unborn babies with severe CDH. The study is aimed to demonstrate the Center’s ability to safely insert and remove the FETO device in severe CDH fetuses.
- The Fetal Center participates in ongoing research trials to advance medicine in the treatment of CDH and other conditions, with the goal of improving patient outcomes, and is one of only three U.S. centers to hold membership in all three key maternal-fetal research networks:
- Pediatric surgeons in the division of General and Thoracic Pediatric Surgery at McGovern Medical School are internationally recognized for providing state-of-the-art neonatal critical care and minimally invasive surgical repair of CDH. The care provided is based on data collected and new insights gained through the International Congenital Diaphragmatic Hernia Study Group and the CDH Registry, which reside at the hospital and medical school. In 1995, the CDH Study Group was founded by McGovern Medical School physicians, affiliated with Children’s Memorial Hermann Hospital, and the voluntary collaborative has gathered data on more than 10,000 babies with diaphragmatic hernia. The registry now represents centers in 14 countries. Information from this registry has been used in more than 40 CDH Study Group reports. These projects evaluated diagnostic and prognostic variables such as preductal oxygen saturation, defect size/anomaly association, and pulmonary hypertension.
Medical journal articles authored or co-authored by physicians affiliated with Children’s Memorial Hermann Hospital (names indicated in bold) include:
- Seminars in Pediatric Surgery – Volume 26, Number 3, June 2017 (Elsevier, Ltd.)
Editor: Daniel J. Ostlie, M.D.; Guest Editor: Kevin P. Lally, M.D., M.S.
- Page 14 – Congenital diaphragmatic hernia: The role of multi-institutional collaboration and patient registries in supporting best practice (By Pamela A. Lally, M.D., Erik D. Skarsgard, M.D. FRCSC, FACS, FAAP)
- Page 32 – Congenital diaphragmatic hernia-associated pulmonary hypertension (By Matthew T. Harting, M.D., M.S.)
- Page 63 – Long-term follow-up of congenital diaphragmatic hernia (By Laura E. Hollinger, M.D., Matthew T. Harting, M.D., M.S., Kevin P. Lally, M.D. M.S.)
- Harting MT, Lally KP, The Congenital Diaphragmatic Hernia Study Group registry update, Seminars in Fetal & Neonatal Medicine (2014), http://dx.doi.org/10.1016/j.siny.2014.09.004