Skip to Content


Find a Doctor

To search Houston doctors, please select a specialty & submit your Zip Code below.

Advanced Search
Search by Doctor's Name

Schedule Now

Dedicated CDH Research

Children who qualify and families who are interested have the opportunity to participate in groundbreaking research studies conducted by the physicians at McGovern Medical School at UTHealth. Affiliated with Children’s Memorial Hermann Hospital, the team of specialists – including fetal surgeons, pediatric surgeons and neonatologists – are dedicated to research and innovation for the prenatal and postnatal treatment congenital diaphragmantic hernia (CDH).

The affiliated team of CDH specialists offers patients and families the opportunity to participate in clinical trials, should they be interested. The team conducts many different types of trials and research, ranging from simple reviews of medical records and outcomes to complex therapy or intervention trials. Here are some examples of the research the team is involved in:

  • Basic science research on the blood vessels of the lungs.
  • Translational research introducing new therapies to patients.
  • Clinical research doing chart reviews and following patient results.
  • Multicenter collaborative research – our center coordinates the International CDH Study group, a consortium of centers who collaborate to evaluate outcomes and improve care.

Contact Us

Research Trials

The team is conducting or participating in active, ongoing CDH trials – [summarized here]:

Severe Arm of TOTAL Trial – offered to qualifying patients at The Fetal Center

Moderate Arm of TOTAL Trial – offered to qualifying patients at The Fetal Center

  • Goal: Determine if blocking the airway before birth improves fetal lung growth and neonatal outcome
  • Intervention: Place a special balloon in the airway
  • Timing: Before birth (~30 weeks gestation)
  • Follow-up: 2 years

Umbilical Cord Blood Trial – offered to qualifying patients at time of delivery at Children’s Memorial Hermann Hospital

  • Goal: Determine if special cells (mononuclear cells) from a child’s own UCB are safe and improve outcome
  • Intervention: Autologous UCB given intravenously
  • Timing: Cells isolated at birth & administered in the 1st week of life
  • Follow-up: 2 years

Milrinone Trial – offered to qualifying patients in the Level IV Neonatal Intensive Care Unit (NICU) at Children’s Memorial Hermann Hospital

  • Goal: Determine if a drug helps improve blood oxygenation
  • Intervention: Administer a drug vs placebo intravenously
  • Timing: Within the first week of life
  • Follow-up: 1 year

iOS / Asthma Trial – offered to patients in the CDH Long-term Follow-up Clinic

  • Goal: Determine if older children have specific restrictive or obstructive airway issues
  • Intervention: None
  • Timing: 2 years old – 18 years old
  • Follow-up: as long as the child is in the clinic

The Fetal Center participates in ongoing research trials to advance medicine in the treatment of CDH and other conditions, with the goal of improving patient outcomes. The Fetal Center is one of only three U.S. centers to hold membership in all three key maternal-fetal research networks:

Pediatric surgeons in the division of General and Thoracic Pediatric Surgery at McGovern Medical School are internationally recognized for providing state-of-the-art neonatal critical care and minimally invasive surgical repair of CDH.

The care provided is based on data collected and new insights gained through the International Congenital Diaphragmatic Hernia Study Group and the CDH Registry, which reside at the hospital and medical school. In 1995, the CDH Study Group was founded by McGovern Medical School physicians, affiliated with Children’s Memorial Hermann Hospital, and the voluntary collaborative has gathered data on more than 11,000 babies with diaphragmatic hernia.

The registry now represents centers in 16 countries. Information from this registry has been used in more than 50 CDH Study Group reports. These projects evaluated diagnostic and prognostic variables such as preductal oxygen saturation, defect size/anomaly association, and pulmonary hypertension.

Meet The CDH Team & Published Works

To meet the affiliated team of CDH specialists and view the medical journal articles on CDH authored or co-authored by physicians affiliated with Children’s Memorial Hermann Hospital, click here.